Clinical Study on Lactomin probiotic effects

Synbiotic (LactominPlus®) (Cheongju-si, Korea) in a powder form was stored at room temperature below 25 C. It was packaged at 6000 mg per pack and contained multiple probiotic strains (Lactobacillus acidophilus La-14, Lactobacillus plantarum Lp-115, and Bifidobacterium animalis subsp. lactis CBG-C10). In conclusion, the results of this double-blind randomized controlled human study demonstrated that the daily intake of multiple strains (L. acidophilus, L. plantarum, and B. animalis subsp. lactics) and FOS for 8 weeks were effective in improving the degree of formed stool and patient-self reported bowel movement satisfaction compared to placebo in FDr patients with high fecal calprotectin levels according to the Rome IV criteria.

In addition, we found a significant increase in Lactobacillales at the order level in the fecal microbiome analysis of the synbiotic group. Given the expected increase in the prevalence of FDr according to the Rome IV criteria for functional bowel disorders, our findings provide a basis for improving bowel symptoms in FDr patients. In conclusion, the results of this double-blind randomized controlled human study demonstrated that the daily intake of multiple strains (L. acidophilus, L. plantarum, and B. animalis subsp. lactics) and FOS for 8 weeks were effective in improving the degree of formed stool and patient-self reported bowel movement satisfaction compared to placebo in FDr patients with high fecal calprotectin levels according to the Rome IV criteria.



Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, GC Genome, Youngin, South Korea