Lactokids + Probiotics

Lactokids + is specially formulated for kids. It has 10 billion active probiotics to boost your child's immunity and build a strong digestive system. It is GMP (Good Manufacturer's Practice) certified by KFDA (Korea Food and Drug Administration). It has the World's First and only Double Microencapsulation by NR Korea which assures Over 90% of the probiotics enters the gut and achieves a very high survivability rate. Lactokids is one of the very few probiotic brands with 9 Probiotic Strains, colostrum, calcium, vitamins B, D and prebiotics for good gut health. (*Currently Refreshing to new packaging for 2024)


Made in Korea

S$70.45 (tax incl.)

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What is Gut Microbiota?

Your child's gastrointestinal microbiota, also known as gut flora or gut microbiota, are the microorganisms that live in the digestive tracts of humans. A healthy gut flora = 80% good bacteria which is the key to good health. Scientific studies have shown that poor intestinal health due to an imbalanced gut flora (usually dominated by pathogenic bad bacteria) is the main cause of many chronic health problems.

Examples of the problems associated with poor gut health

Unhealthy weight - Obesity, Overweight
Loose Stool - Clear sign of poor bowel health
Poor Immunity - Fall sick regularly
Poor skin condition - Acne, Eczema, Skin flares
Poor mental health - Lethargic, tired regularly, difficulty remembering
Irregular Bowels - Difficulty moving bowels, Poor digestive health
Stomach Discomfort - Pain in stomach
Bad Breath - Especially in the mornings, built up of bad bacteria

Lifestyle that can destroy your child's good bacteria

Our Everyday Lifestyle can cause havoc to our health

  • High sweet intake - Can cause bad bacteria to repopulate faster
  • Lack of sleep, rest and increase stress - Affects microbial diversity
  • Lack of fibre - Most kids do not like a high fibre diet, and probiotics thrive on prebiotics (High fibre)
  • Frequent use of antibiotics - Destroys all good and bad bacteria, affects the gut flora diversity greatly
  • Pollution, artificial food colourings, tainted food sources - alter the gut microbial diversity
  • Chlorinated, Unfiltered water with chemicals - can affect microbial balance of bacteria
  • GMO food - Highly popular chemical which farmers spray on their GMO crops, glyphosate can negatively impact bacteria in the gut. eg. procssed foods - chicken nuggets, fries, cheesy puffs, etc

Probiotics is key to a Healthy Gut Microbiota

How does probiotics help you to achieve a healthy gut flora?

Probiotics are friendly, good beneficial bacteria that provide health benefits to the host. When consumed in adequate amounts, they can improve the health of your digestive tract, restore the good bacteria and repopulate more in your gut to replace the bad bacteria that live along your gastrointestinal walls. Without good bacteria, bad bacteria will occupy the intestinal walls and colonise.

Probiotics also help the body to absorb nutrients and vitamins better. It eliminates toxic compounds from the digestive tract. Replenishing the right and good type of probiotics is highly important to maintain a good gut flora.

See the Importance of maintaining 80% good bacteria balance in your child's body!

Promoting Better Digestive Health

Let's be honest. Digestive problems are no fooling around: occasional upset stomach, gas, bloating, or diarrhoea are uncomfortable and can worsen quality of life. Many of these digestive issues are mainly caused by an imbalance of good bacteria in the digestive tract. Fortunately, the probiotics in Lactokids + help restore the natural balance of good bacteria in your child's intestines to help their digestive system work better, strengthen their immunity and keep them strong.

Strengthens your child's immune function

Probiotics are composed of helpful bacteria to help support immunity and healthy digestion. We usually think of bacteria as something that can cause disease, but probiotics are the good bacteria that can be very effective in keeping your gut healthy.

With convenient packaging, Lactomin and Lactokids are designed to be quickly sprinkled on the tongue, on cold food or in a cold beverage, this probiotic helps your body maintain a balance of good bacteria in the gut while promoting immunity and aiding your body's natural defenses.

How can you be sure your probiotics product is delivering the benefits you need? What matters most is knowing what strains are included in the product and that there's clinical support for those digestive and immune benefits. "It's less about the billions of probiotics but actually how many of the billions do survive and actually reach your gut to repopulate".

Lactomin and Lactokids was designed and formulated with the right balance of the right strains at the right levels for digestion and immune health." A complete and holistic kids probiotics. 

Eczema or Atopic Dermatitis

Children with atopic dermatitis show clinical improvement after lactobacillus exposure.
The effects of L.paracasei (LP) and L.fermentum (LF), when used in combination, showed the supplementation resulted in clinical improvement in children with AD. The FDLQI and CDLQI scores were lower in the LP, LF mixture group than in placebo group (p=0.02 and 0.03). In subgroup analysis, SCORAD scores significantly decreased after probiotic treatment especially in children younger than age 12. This shows, Lactokids + has a positive effect on AD, and helps to prevent and relieve AD in children. 
Clin Exp Allergy cea 12489

Why Lactokids + Probiotics?

Lactokids + is specially formulated for infants and kids. It has 10 billion active probiotics to boost your child's immunity and build a strong digestive system. It is GMP (Good Manufacturer's Practice) certified by KFDA (Korea Food and Drug Administration). It has the World's First and only Double Microencapsulation by NR Korea patented technology which assures Over 90% of the probiotics enters the gut and achieves a very high survivability rate. Lactokids + is proven and backed by extensive and credible clinical trials.

Probiotics Made Specially for Infants and Kids

Childhood is a time of constant development, and as parents we do our best to encourage the healthy growth of our kids. We give them fruits for their fibre, fish for their brain and milk for their bones, but did you know how important it was to establish a healthy digestive and immune system at a young age?

A child’s digestive and immune system is established during the first few years of their life, with the majority of this development happening within the digestive tract. As a child grows, through the development stages, their digestive system has to adapt to changes in diet, stomach bugs, and even minor fluctuations like when they consume too much sugar or salt.

All these changes can result in occasional digestive upset. That is why introducing healthy bacteria into the body at an early stage is an important and positive step for the digestive and immune health of your child.

What are the benefits of supplementing your kid with Lactokids?

By supplementing your kids a probiotic supplement like Lactokids, you’re introducing good bacteria into their gastrointestinal tract. Taken every day, this good bacteria helps maintain the natural balance in your child’s digestive and immune system, allowing their bodies to function properly and support their general well-being.

Kids are unable to express their discomforts or what is troubling them, but we can! So as a parent, you can play that vital role in developing a strong immune and digestive system for your child!

Lactokids + is made in Korea and specially formulated for children from infant to age 16. Mothers want the best for their children and with Lactokids+, they will have a complete probiotic formula which emphasizes safety and efficacy.

It is 100% natural, specially for infants and children, probiotics are essential for strengthening their line of defense against harmful bacteria. Probiotics maintains the balance between beneficial and harmful microorganisms found in our digestive tract.

Probiotics is essential for a healthy functioning digestive system, which in turn is crucial to the optimal health of a child. Lactokids + is all natural, developed through extensive scientific research, trials and tests.

It promotes better and stronger digestive health through a unique (USA) patented combination of Lactobacillus acidophilus, Bifidobacterium longum and S.faecalis / S. thermophilus. With a further addition of 6 extensively researched strains Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus fermentum and Bifidobacterium bifidum are unique and differentiated from other children probiotics with addition of vitamins B1, B2, B5, B6, B9 and D3, added Colostrum, Calcium and Prebiotics helping to promote and strengthen the growth of a child.

It is trusted by millions worldwide and can be taken everyday to build a strong immune system.

Colostrum: When the mother's colostrum is introduced to the infant, it "turns on the child's immune system" It has incredible immune-balancing benefits from improved gut stability to nutrient absorption. It provides immunological balance, reduce inflammation and increases energy

Calcium: Helps to build and strengthen bones 

Vitamins B1 and B2
: Helps the body produce energy and affect enzymes that influence the muscles, nerves and heart.

Vitamin B5: Helps to break down fats and carbs for energy. It promotes healthy skin with the ability to reduce signs of skin aging.

Vitamin B6: Helps the body break down protein and helps maintain the health of red blood cells, the nervous system and parts of the immune system.

Vitamin B9: Helps in production of red blood cells.

Vitamin D3: Helps the body use calcium and phosphorus to make strong bones and teeth.

Prebiotics: Added prebiotics to aid the growth of probiotics

Lactokids + is one complete and holistic probiotic product that meets all your child's immune and digestive needs.

Powerful benefits of Bifidobacterium probiotic strain (In Lactomin/ Lactokids / Lactocran)

Recently in 2021, some interesting data have emerged regarding gut health and SARS COV-2 infections.

It is known that children for the most part have healthier guts than adults. The initial hypothesis focused on what in particular afforded children this protection.

They found significant data linking the gut microbiome to this Immuno-protection. Children’s gut microbiome differs slightly from adults.

We all know the benefits of probiotics and many practitioners recommend that probiotics contain a particular species called Bifidobacterium. Well, it turns out that children have much higher levels of Bifidobacterium in their guts than adults do.

This species actually constitutes the major gut microbe present in children under the age of 10.

These levels begin to decrease as we age and are very low in the elderly and adults with certain conditions such as obesity and diabetes. A comparison of Bifidobacterium concentrations in the gut of children ranges from 60-80% compared to 20-40% in adults and less than 10% in the elderly with some high-risk groups as low as 1%.

Bifidobacterium has been investigated extensively in previous studies and has been found to provide specific benefits to the immune system and in modulating immune cell mediators.

They discovered that many of the immune signaling mediators and pathways were the same ones affected in severe SARS COV-2 infections. Interestingly enough, although Bifidobacterium levels decline with age, when posed with an infection or perceived intruder to the body, these pro-inflammatory mediators lead to a hyper exaggerated immune response which leads to tissue damage.

In these high-risk individuals, the immune system overreacts, leading to severe illness. Bifidobacterium has been shown to down-regulate Interleukin-6 levels and actually increase certain anti-inflammatory markers.

Bifidobacterium thus represents a very viable and low-risk option for prevention and building up immunity for the individual.

Choose a probiotic with the powerful probiotic immuno effect of bifidobacterium.

Why Probiotics?

70% of your child's body's immune system is managed in the gut. It supports your child's immunity by stimulating the body's natural defences in the gut. It lines the intestines with a protective layer of beneficial bacteria. Shouldn't you be helping your child to build a strong digestive system to build a strong immune function, since 70% of the immune system resides in the gut.

It maintains the balance between beneficial and harmful microorganisms found in our digestive tract. It is essential for a healthy functioning digestive system. Lactokids + is clinically proven with clinical studies. It is effective in relieving stomach upset and constipation. It also helps reduce gas and stomach bloating. It promotes better digestion and immunity. It also helps relieve atopic dermatitis.

Lactokids + probiotics is specially for infants, toddlers, pre-schoolers and primary schoolers (up to 12 years old)

It is 100% natural, GMP Certified by KFDA (Korea Food and Drug Administration). It is proudly made in Korea and trusted by millions worldwide. It has 10 Billion CFU and 9 key probiotic strains

  • Lactobacillus acidophillus
  • Lactobacillus rhamnosus
  • Lactobacillus plantarum
  • Lactobacillus casei
  • Lactobacillus paracasei
  • Lactobacillus fermentum
  • Bifidobacterium bifidum
  • Bifidobacterium longum
  • S. thermophilus

How good a probiotic is not in the count but in survivability of strains

The survival of probiotics in nature are highly vulnerable to many factors from temperature, humidity to stomach acids. Little is communicated to consumers about survivability. Alot of communication is on which probiotic has more count in billions compared to another, and you will think more is better. However think again. You can consume a 100 billion count probiotic and only absorb less than 2% of the 100 billion into your gut.

Why? Simply the probiotics are non-protected and 98% of the strains would have never made it pass the stomach. Other factors include temperature and humidity. 59% of probiotic strains would have been killed in storage conditions, temperature fluctuations, humidity, etc... Even probiotics in capsules, are supposed to stay in their capsules. However when capsules are opened to consume the contents, the moment the capsule is open, the lactic acid bacteria is exposed and immediately dies.

Did you know the intestinal tract is as long as a double decker bus! Can you imagine without protection, the probiotic strains will never have made it to the intestines or through the intestinal walls.

Lactokids has a unique SPCC double microencapsulation protective system, which is patented and protects every single strain from temperature, humidity, to stomach acidic conditions. It can withstand storage temperatures of up to 33 Degrees. Wheras most probiotic brands have to be stored at or below 25 degrees. In hot and humid Singapore, or South East Asia, it is almost impossible to store below 25 degrees, unless refrigerated or temperature controlled.

With SPCC Double coating, consisting of 1st and 2nd encapsulation followed by a unique matrix barrier to further protect the probiotic strains.The uniquely safe and natural protective layer is formed by organic properties only. The SPCC microencapsulation acts as a physical barrier to protect the probiotic strains from harsh conditions of the body as well as environmental stress. Releasing the probiotic strains in the strategic areas of the intestines, assures optimal delivery of strains and increase the rate of intestinal colonisation and keeps the intestinal walls healthy.

The Lactokids advantage

10 Critical and Essential areas to look out for in a good kids probiotic brand.

  • Quality of strains
  • Are the strains proven
  • Multi-Strains Vs Single Strain
  • How many grams of active strains per sachet
  • Survivability of strains
  • Added colostrum, calcium, vitamins and prebiotics for helping to build your child's growth development
  • Any positive effect after taking the product
  • Where is the product made
  • Certifications, Safety and Efficacy
  • Recommended and Optimal CFU, not necessary to choose over hundred of billions. (Unless there is a medical condition)

Dosage Directions

Recommended Dosage (After Meals)

For immune function & build a strong digestive system:

1 sachet daily: infants from 0 - 36 months

2 sachets daily: 36 months and above (up to 12 years old)

For relieving stomach upset / diarrhea

2 sachets for relieving stomach upset, constipation, or bloated stomach - Infants from 0 - 36 months

3-4 sachets for relieving stomach upset, constipation, or bloated stomach - 36 months and above


  • Can be taken directly (Simply tear along the perforated line on the sachet)
  • Can be taken dissolving in room temperature water, warm milk or food.
  • Avoid mixing with Hot Water.

Shelf Life

  • 3 Years


  • No refrigeration required, Specially sealed for freshness.
  • Store in a cool dry place, avoid direct sunlight.

This product is not intended to treat, diagnose, cure or prevent any disease

Lactokids unique delivery process
Lactokids is good for kids
Our range of probiotics
What makes Lactokids tick
Deep explanation on why our probiotics
Kids review on Lactokids
Understanding why our probiotics
Kids Review on Lactokids
Why probiotics are important?


  1. Where is Lactokids made?
    Lactokids is proudly made in Korea
  2. What is colostrum in Lactokids? 
    Lactokids has Bovine colostrum — This comes from cows, and it is the type of colostrum that is used for most colostrum supplements. It contains many of the same nutrients found in human colostrum. Newborns have immature digestive and immune systems, so the enzymes, antibodies, and growth factors colostrum provides promote growth and fight disease. Colostrum has become a popular nutritional supplement because it is a rich source of enzymes, antibodies, and growth factors not found in other dairy products and is highly beneficial for the development of children.
  3. Where is colostrum from? 
    Lactokids has both colostrum (USA) and colostrum basic protein (New Zealand).
  4. Can vegetarians take Lactokids? 
    Lactokids has Bovine colostrum — This comes from cows, and it is the type of colostrum that is used for most colostrum supplements. Colostrum is a dairy product, it is neither meat nor vegetable, therefore it depends largely on your personal choice. It contains many of the same nutrients found in human colostrum.
  5. Is Lactokids safe for pregnant women?
    Yes, Lactokids is 100% safe for pregnant women. However if you experience hypersensitive reactions, please consult your medical professional for medical advise.
  6. Is Lactokids safe for those with lactose intolerance?
    Lactose intolerance (LI) occurs when the small intestine does not make enough of an enzyme called lactase. Your body needs lactase to break down, or digest, lactose.
    The diagnosis of LI based on patients' symptoms is sometimes problematic, since these symptoms are not specific and may differ from one patient to another.
    The presence of lactase producing bacteria especially Lactobacillus acidophilus, contribute to the digestion and absorption of lactose. It was also found that the presence of Streptococcus thermophilus alleviate lactose intolerance through their ability to produce lactase enzyme. Lactokids + is safe for children with LI and have both active Lactobacillus acidophilus and Streptococcus thermophilus strains which can help improve LI condition.
    As symptoms of LI are not specific and differ from one individual to another. LI conditions can range from mild to severe cases. It is still recommended and best to seek your medical professional for medical advice on unique cases.
  7. Does Lactokids cause you to gain weight?
    The taste of sweetness is from the added prebiotics (Fructo-oligosaccharide or FOS) which are plant based and are natural. FOS have a number of interesting properties, including a low sweetness intensity; they are also calorie free, and are considered as soluble dietary fibre. Furthermore, FOS have important beneficial effects such as low carcinogenicity, a prebiotic effect, improved mineral absorption and decreased levels of serum cholesterol, triacylglycerols and phospholipids. Currently FOS are increasingly included due to their prebiotic effect to stimulate the growth of beneficial intestinal microflora. With the combination of probiotics and prebiotics, it works strongly together to grow and populate good beneficial bacteria in the digestive system.
    Lactomin and Lactokids are probiotic health supplements which are not unhealthy and consumption of it has no impact on weight gain. It does not add calories to your diet.
    It is 100% safe, and highly beneficial to build immunity and healthy digestion.
  8. Where is Lactokids sold?
    Lactokids + is sold at Guardian, Watsons pharmacies and medical clinics.
  9. Can Lactokids help relieve eczema?
    Lactokids has active probiotic strains Lactobacillus paracasei (LP) and Lactobacillus fermentum (LF). Studies have shown children with bio markers with atopic dermatitis (eczema) who received LP, LF, and LP + LF mixture showed lower SCORAD scores than the placebo group (P < 0.001).
    Supplementation of a probiotic mixture of LP and LF is associated with clinical improvement in children with AD.
  10. What is the ideal age for supplementing Lactokids?
    Lactokids is specially formulated for infants to kids age 12. It is recommended from ages 0 and up to 12 years old. Please see the recommended dosage on the packaging. For infants 0 - 36 months, Lactokids can be mixed with room temperature water, milk or supplement with food.
  11. I noticed when Lactokids is mixed with water, there is a small brownish residue at the bottom of the cup
    Lactokids is made in Korea, 100% safe and of Highest Quality. It is manufactured under strictest and stringent lab and manufacturing conditions. It is ISO 9001, SQS, CGMP, CCM, HACCP certified.  The brownish residue is due to the vegetable cream powder when mixed with water in Lactokids, it is for supplementary function containing vitamins and minerals. Brownish residue is the natural property of vegetable cream powder. Vegetable cream powder is added as a supplementary function which is widely added in health functional foods worldwide.
  12. How do you store Lactokids? Recommended storage conditions are non refrigerated, keep away from direct sunlight, room temperature.
  13. If Lactokids is delivered via online delivery, and is kept in transit which might be exposed to warm conditions, will it compromise the product? Lactomin / Lactokids probiotics are double microencapsulated which are double protected from temperature fluctuations as well as sealed in high quality sealed aluminium packaging which adds a further layer of protection. Therefore it will not compromise the quality of the product.
  14. If my child has diarrhoea, how many sachets do i give to help relieve it? Please refer to the dosage instruction on the packaging. Helping to relieve diarrhoea, constipation, (infants - 3 yrs old: 2 sachets.) (Children 3yrs and above: 3-4 sachets) All at one go, monitor to next meal.
  15. When is the best time to take Lactokids? It is perfectly fine to take Lactokids anytime of the day. However it is recommended to be taken after food (start of the day), after breakfast.
  16. What is Lactokids good for? Lactokids has shown to help build a strong digestive system, builds strong immune function due to its strains, colostrum & vitamins, it helps relieve stomach upset (diarrhoea), constipation, bloated stomach, and eczema.
  17. Is Lactokids Halal Certified? It is currently not Halal certified, we will update again on the certification.


"My 10 year old son was having poor appetite and tummy issues. Stomach upset for a few days. A friend recommended Lactokids, so i bought from watsons and  tried on him. Within 2 days, his stomach condition improved, stomach upset was gone. Appetite improved over the next few days! He loves taking it, which is really good. thank you lactokids!"

- Quinny Loh

"Lisa had poor immunity since young, i was never able to strengthen her immunity. She fell ill often and was on antibiotics quite regularly. Was very concerned, till a friend introduced lactokids to her, she started taking it, her gut improved, followed by her immunity, within a week, she was no longer lethargic, the next week she was stronger and in that month, she did not fall sick! Usually she will fall sick 2-3 times a month. Am so glad Lactokids has helped strengthen her immunity."

- Belle Tan

"A friend recommended Lactokids to me, i gave it to my 5 year old son who was having constant diarrhea problems. It helped him, after a few rounds of 3 sachets per day, his gut improved tremendously and now is as good as new! He does not have any diarrhea problems anymore, Highly recommend for kids with digestion issues.

- Nikki Toyo

"My 4 yr old son had bad constipation, he was constipated for 2 days and was very uncomfortable. He started taking Lactokids, and the next day, he started to answer the call, within a day or 2, his constipation was gone and was back to normal. Ever since then, we give him lactokids daily and he has never had another constipation episode. Highly recommend Lactokids!!

- Marcus Pang

"I received a free sample of Lactokids + from Watsons pharmacy. My 5 yr old daughter had stomach issues and some minor eczema. I allowed her to try Lactokids, and she loved it! Getting kids to take suplements can be tedious, however lactokids seemed to tick with her. So i bought 2 boxes to let her try and see whether there is any improvement. In a week, her stomach issues were improved and she was back to her normal routine. In 4 weeks, her eczema had cleared! I am so impressed with Lactokids and is one kid's probiotic i highly recommend to parents!"

- Melissa Goh

"My 7 year old daughter loves taking lactokids! She just can't stop popping lactomin! Good thing it a supplement, if not i will be in trouble. She takes once a day, sometimes twice. I have seen her gut improved as she does everything with ease and daily. The taste is so good, she says its like taking "Horlicks sweet!" With a healthy digestive system taken care of, she can focus on her priorities."

- Jessie Ong

"My 3 year old son loves Lactokids! The ease of giving him, makes it so easy for him to take daily. I am so happy with this probiotic, as i have seen very positive results in his digestion and helping his eczema skin condition. Thank you Lactokids!"

- Gary Tiong

"Was introduced probiotics by my PD when my kids was a year old, however it was very expensive and my daughter disliked the taste. After a while, i gave up and wasted it. A friend of mine introduced Lactokids recently, let her try as she is 2 years old now, was sueprised she love taking it, and wanted more! I decided to buy Lactokids as i believe in probiotics helping my child's gut, with her liking was a bonus as i need not struggle with her not wanting to take probiotics daily."

- Lucy Tay

"Whenever my kids are on antibiotics, they usually have diarrhoea, took Lactokids to help relieve the diarrhoea, and supplement their gut with good bacteria. Really works! Diarrhoea stopped and been taking it daily!"

- Xu Jiamin

"Lactokids is not just probiotics, it has vitamins, colostrum, calcium and prebiotics! It's good tasting, shows results and value for money! Love it! My kids never fuss taking probiotics everyday"

- Jonathan Lee

"Hi there, just to let Lactokids know that ever since my daughter who is 6 months old has been having bloated stomach daily. She has been taking Lactokids daily and has helped to prevent bloatedness, i have seen her gut health improved and also has helped in constipation. I will continue to buy Lactokids because it works! Thank you"

- Sandra Chan

Lactokids SPCC Double Protective Coating

Research has shown the intestinal survival rate for Lactokids Probiotics after a 30 days duration at 37 degree celcius, achieves above 90% viability. As compared to probiotics without any protection with viability of less than 50%. This is very important as it determines the efficacy and viability of the probiotics. Lactokids high survival rate ensures optimal delivery of the strains to the small intestines to ensure optimal proliferation of strains in the intended intestinal areas.

Change in PH environment and SPCC Protection

The nature of probiotics are highly vulnerable to change in PH environment. However with SPCC double protection, research has shown the change of PH does not affect the protective layer on the probiotic strain. At PH 2.4 (which is the environment in the stomach), the probiotic is unaffected due to the protective layers protecting the strain. As it travels into the intestinal area, at Ph 6.8, the coating is gradually dissolved, releasing the probiotics and ensuring high stability and efficacy. This is why Lactokids produces positive results and ensures a high effective rate.

SPCC Double Protection Coating under magnification

SPCC Double Coating is a patented eco-friendly coating technique designed to revolutionise the survivability of probiotics through rigiously tested protective coating, hence protecting the probiotic against temperature, moisture and pressure. This ensures the probiotic strain reaches the intestines live, and are unaffected by gastric acid and bile acid.

At the same time, a SPCC Double Coating has superb acid resistance properties, which support active proliferation of probiotics by promoting probiotics not to be dissolved by gastric acid and to precisely react to changes in pH, dissolving well in small intestines when being close to neutral.

Series I Clinical Studies Program

Documented Series I ​For Series One Clinical Studies Patients taking part in the clinical trials stopped using other drugs such as antibiotics, hormones, adsorbents, astringents or lubricants before the trials began. Effect of the microbe composition of this invention on treating diarrhea and constipation. 540 patients (inc adults and children) The total effective rate for the test group was 97.5% From the results of the clinical trials. it can be concluded: The microbe composition of this invention is effective in treating various kinds of diarrhea.

This invention provides a microbe composition comprising of Lactobacillus acidophilus, Bifidobacterium and Streptococcus faecalis. The combination of three bacterium strains has an advantage over a single bacterium strain preparation since each of the three bacterium strains has its characteristics and specialized roles and is synergetic with each other.

Third Series Clinical Studies Program

Expanded program for further clinical studies

Conducted at 80 hospitals in Beijing and Shanghai further tested the efficacy of the microbe composition in 1,321 patients inc 866 adults and 455 children. Treatment of constipation was conducted on 94 adults and 61 children, the total marked effective rate was 77.5% and 88.5% respectively.

Improvement on atopic dermatitis for children

Children with atopic dermatitis show clinical improvement after Lactobacillus exposure.

To assess the effects of Lactobacillus paracasei (LP) and Lactobacillus fermentum (LF), and their mixture on the disease severity, quality of life, and immune biomarkers of children with AD.

A double-blind, prospective, randomized placebo-controlled study was conducted on 220 children aged 1-18 years with moderate-to-severe AD (Trial number: NCT01635738). The children were randomized to receive LP, LF, LP + LF mixture, and placebo for 3 months. Changes in severity scoring of atopic dermatitis (SCORAD), Family Dermatology Life Quality Index (FDLQI), and Children's Dermatology Life Quality Index (CDLQI) scores in the different groups and at different visits were evaluated.

Skin prick tests, levels of IgE, IFN-γ, IL-4, TGF-β, and TNF-α, and urine biomarkers were also evaluated. Children who received LP, LF, and LP + LF mixture showed lower SCORAD scores than the placebo group (P < 0.001), and this difference remained even at 4 months after discontinuing the probiotics. The FDLQI and CDLQI scores were lower in the LP, LF, and LP + LF mixture group than in the placebo group (P = 0.02 and 0.03). IgE, TNF-α, urine eosinophilic protein X, and 8-OHdG levels decreased, whereas IFN-γ and TGF-β increased in the probiotic groups, but these did not reach statistical significance except for IL-4 (P = 0.04).

In subgroup analyses, SCORAD scores significantly decreased after probiotic treatment especially in children younger than age 12, with breastfeeding > 6 months, and with mite sensitization (P < 0.001).

Supplementation of a probiotic mixture of LP and LF is associated with clinical improvement in children with AD.

Clin Exp Allergy. 2015 Apr;45(4):779-87. doi: 10.1111/cea.12489.

A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants.

This clinical trial was carried out to determine whether oral treatment with a commercial probiotic formula containing Bifidobacterium lactis and Streptococcus thermophilus would reduce the frequency of antibiotic-associated diarrhea (AAD) in infants.

There was a significant difference in the incidence of AAD in the children receiving probiotic-supplemented formula (16%) than nonsupplemented formula (31%).


Immune modulatory effects of probiotic Streptococcus thermophilus on human monocytes

Commensal bacteria and probiotics have made their entry to the mainstream of healthcare and contribute to immune homeostasis in the gastrointestinal tract as well as conferring beneficial immunomodulatory properties that assist in the maintenance of a healthy immune system.

We assessed the immune modulatory effects of ST on human monocytes and demonstrated that it delivers a range of potential immunomodulatory and anti-inflammatory properties.

The data exhibits a predominant anti-inflammatory profile of cytokine, chemokine and cell markers induced by ST.Therefore, the use of ST may be an efficacious approach for the treatment of select autoimmune diseases without using broad immunosuppression caused by currently available treatments for autoimmune disorders.

Supplementary work is required to determine whether ST bacteria displays similar anti-inflammatory effects in vitro and in vivo in compromised immune disorders/ models such as inflammatory bowel disease, multiple sclerosis and allergies.

Source: Journal of Clinical Gastroenterology, 01 May 2005, 39(5):385-389 DOI: 10.1097/01.mcg.0000159217.47419.5b PMID: 15815206

Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

IBD is generally associated with the change of the immune system and gut microbiota, and the conventional treatments usually result in some side effects.

Bifidobacterium longum, as colonizing bacteria in the intestine, has been demonstrated to be capable of relieving colitis in mice and can be employed as an alternative or auxiliary way for treating IBD.

Here, the mechanisms of the Bifidobacterium longum in the treatment of IBD were summarized based on previous cell and animal studies and clinical trials testing bacterial therapies.

Many clinical trials have shown that using Bifidobacterium longum can effectively improve the symptoms of IBD.

Source: Published online 2021 Jul 23. doi: 10.1155/2021/8030297

Evaluating the encapsulation of the lactic acid bacteria in simulated gastrointestinal conditions. (SPCC Clinical Study, Lactokids strains, Korea)

This study aimed to evaluate the viable stability of probiotic bacterial cells (Lactobacillus plantarum, Lactobacillus fermentum, Streptococcus thermophilus, Lactococcus lactis and Enterococcus faecium) that were coated with SPCC by comparing their resistance in simulated intestinal fluid (with pancreatin) and simulated gastric fluid (with pepsin) in vitro with that of the non-coated free cells.

The results showed that the SP coated cells exhibited considerably greater resistance to the simulated gastric fluid than the activated cells (p <0.001), showing that the SP coating may enhance the survival of probiotic bacteria after consumption during their transit through the GI tract after freeze-drying process.

The viability of SPCC coated cells was significantly higher (p < 0.001) than that of the activated non-coated cells. ( Refer to table 1). The average survival rate of the activated non-coated free cells was 50-60% after 4 h of exposure. In contrast, the SP coated cells showed a higher survival rate (96-99%) (Table 1).

All SPCC coated freeze-dried cells were significantly higher than that of the activated non-coated cells in survival rate (96-99.9%) (Table 2).

Morphological characterization of cells by scanning electron microscopy

The scanning electron microscope photomicrographs showed the appearance of the freeze-dried cells (Fig. 1).

SPCC encapsulation formed thin layers of embedded bacterial cells and showed a smooth surface structure (Fig. 1c). In contrast, non coated free cells showed a porous rough surface (Fig. 1a and b)

The majority of tested SPCC probiotic bacteria were found to be more resistant to simulated gastrointestinal conditions than that of activated non-coated. Our results were consistent with studies of cell coating technology that discovered the increased survival of probiotic bacteria under acidic conditions. SPCC encapsulation formed thin layers of embedded bacterial cells and showed a smooth surface structure (Fig. 1c).

In contrast, non-coated free cells showed a porous rough surface (Fig. 1a and b). Our results agree with other studies which observe the encapsulated matrix type of SPCC encapsulation. The variations in microstructures in encapsulated cells can be attributed to the differences in viscoelastic and film forming characteristics of each wall material.

Encapsulation could block direct contact between bacterial cells and harsh gastrointestinal environments. The capsule that encloses the probiotic bacterial cells dissolves over time, helping to settle bacteria in human intestinal tract.