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Survivability of beneficial bacteria is key to a superior probiotic product

Posted on30 Dec 2019
This is the most important factor to consider in a probiotic supplement. Make sure the live cultures in your supplement can actually reach your intestines. That’s why you need an encapsulation of each probiotic strain. Scientists designed these special dual coating to protect the probiotics from stomach acid. They release the probiotics in the small intestines where they are most effective.

They start disintegrating approximately 60-120 minutes later than a typical immediate release capsule. They significantly reduce opportunity for early probiotic degradation. Other capsules dissolve in the stomach within minutes of ingestion. It severely limits their ability to affect your digestive health. So it doesn’t matter what variety of strains or how many CFUs the capsule contains.

Only about 10% of the bacteria will reach your intestines. These probiotics will have SOME positive impact on your health. Yet, it will be minimal compared to the probiotics in special protective capsules. Lactomin and Lactokids can make a difference in your digestive health. You need a probiotic supplement that uses a delayed release technology. The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract.

However Lactomin / Lactokids have developed a special patented double microencapsulation technology, using water properties only and guarantees the survivability of probiotic strains right to the intestines. Microparticulate delivery systems are an interesting and promising option when developing an oral controlled release system.

The objective of this paper is to take a closer look at microparticles as probiotic delivery devices for increasing efficiency of probiotic delivery, improving the release profile and probiotic targeting. In order to appreciate the application possibilities of microcapsules in probiotics, some fundamental aspects are briefly reviewed. Introduction Controlled probiotic delivery technology represents one of the frontier areas of science, which involves multidisciplinary scientific approach, contributing to human health care. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, and improved patient compliance and convenience.

By doing so, the treatments that would not otherwise be possible are now in conventional use. This field of pharmaceutical technology has grown and diversified rapidly in recent years. Microcapsules continue to be of much interest in controlled release because of relative ease in design and formulation and partly on the advantages of microparticulate delivery systems.

The latter include sustained release from each individual microcapsule and offer greater uniformity and reproducibility. Additional advantage over monolithic systems containing multiple doses is the greater safety factor in case of a burst or defective individual in subdivided dosage forms.

Finally, it has been argued that multiple particle systems are distributed over a great length of gastro-intestinal tract, which should result in, (a) lowered local concentrations and hence reduced toxicity or irritancy, and (b) reduced variability in transit time and absorption rate Microencapsulation can be used to prepare enteric-coated dosage forms, so that the medicament will be selectively absorbed in the intestine rather than the stomach.

It has been used to protect bacteria strains from environmental hazards such as humidity, light, oxygen or heat.

Source: https://www.ncbi.nlm.nih.gov
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