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Unique Double Protection on Probiotics

Posted on25 Oct 2019




The benefits of Double Noltec Microencapsulation of lactic acid bacteria in Lactomin & Lactokids

  1. Stability against gastric fluid and bile acid
  2. Stability during storage and distribution Protects and provide optimal release of the lactic acid bacteria in the intestinal gut.
  3. It is very effective in our intestine because it is completely unaffected in stomach acid and easily disintegrate in human intestine.
  4. NOLTEC is microencapsulated in low temperature (under 33 degrees) using water only, No organic solvents.
  5. NOLTEC microencapsulation is developed first in the world with outstanding properties of enteric double coating.



The two layers of microencapsulation consists of primary (NOLTEC) and secondary (Enteric) coatings. Research has shown a double microencapsulation of probiotic strains has a very high survival rate of over 90%, this concludes a double microencapsulation with 3 / 10 billion strength has an equivalent effect to a non encapsulated strength of 30 billion. & 100 Bil.

Why? Because the primary NOLTEC encapsulation preserves the lactic acid bacteria from the first enteric coating material, a mucous membrane adhesion in the intestinal wall to maximise the fixation in the membrane. The secondary enteric encapsulation endures gastric acid for over two hours, disintegrates in intestinal juice promptly. It is unaffected in PH1.2 for 2 hours and easily disintegrate in PH 6.8 within 5 minutes The development of oral controlled release systems has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of gastrointestinal tract.

Microparticulate delivery systems are an interesting and promising option when developing an oral controlled release system. The objective of this paper is to take a closer look at microparticles as probiotic delivery devices for increasing efficiency of probiotic delivery, improving the release profile and probiotic targeting. In order to appreciate the application possibilities of microcapsules in probiotics, some fundamental aspects are briefly reviewed. Introduction Controlled probiotic delivery technology represents one of the frontier areas of science, which involves multidisciplinary scientific approach, contributing to human health care.

These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, and improved patient compliance and convenience. By doing so, the treatments that would not otherwise be possible are now in conventional use. This field of pharmaceutical technology has grown and diversified rapidly in recent years. Microcapsules continue to be of much interest in controlled release because of relative ease in design and formulation and partly on the advantages of microparticulate delivery systems.

The latter include sustained release from each individual microcapsule and offer greater uniformity and reproducibility. Additional advantage over monolithic systems containing multiple doses is the greater safety factor in case of a burst or defective individual in subdivided dosage forms.

Finally, it has been argued that multiple particle systems are distributed over a great length of gastro-intestinal tract, which should result in, (a) lowered local concentrations and hence reduced toxicity or irritancy, and (b) reduced variability in transit time and absorption rate. Microencapsulation can be used to prepare enteric-coated dosage forms, so that the medicament will be selectively absorbed in the intestine rather than the stomach. It has been used to protect bacteria strains from environmental hazards such as humidity, light, oxygen or heat.

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