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Vaccine efficacy shows promising research with gut microbiota

Posted on22 Jun 2021
Varying immune response to vaccinations could be countered with microbiota-targeted interventions helping infants, older people and others to take full advantage of the benefits of effective vaccines, Australian and US experts say.

A comprehensive review in Nature Reviews Immunology concludes that evidence is mounting in clinical trials and other studies that the composition and function of individuals' gut microbiota are "crucial factors" in affecting immune responses to vaccinations. Vaccine protection is induced by B cells that produce antigen-specific antibodies but T cells also help mediate the protection induced by some vaccines.

"Our study found increasing evidence that gut microbiota—which is highly variable between individuals, over the course of life and between various populations around the world—as a crucial factor modulating B and T cell immune responses to vaccinations," says co-author, Flinders University Ph.D. candidate Saoirse Benson.

"A better understanding of how the microbiota regulates these vaccine responses may also inform the use of more tailored population-specific adjuvants to enhance responses to vaccinations," she says. "There is more we can do to optimize existing vaccine effectiveness by understanding more about gut microbiota and interventions such as prebiotics and probiotics."

Keeping a stable, healthy gut microbial population is mutually beneficial to us and the bacteria. In exchange for nutrition and a comfortable habitat, the microbe community returns the favor by providing us with health benefits, which we are now starting to understand.

In general, Probiotics help to keep and maintain a good microbiota for humans.

Source Medical Express